Something important is happening as the coronavirus crisis continues. Estimates of its lethality keep going down. On March 31, the White House estimated that, even with social distancing policies in place, between 100,000 and 240,000 Americans would die of COVID-19. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, recently indicated the government’s estimates will soon be revised downward.
The University of Washington model — which has been cited by the White House — predicted on March 26 that, assuming social distancing stays in place until June 1, U.S. deaths over the next four months would most likely be around 81,000. By April 8, it had made more than five revisions, to get down to 60,415. That’s on par with the number of people estimated to have died from the flu in the 2019-2020 season.
What is going on? Perhaps social distancing has worked better than was imagined. But still, there is a puzzle about the numbers. Predictions for hospitalization rates have also proven to be substantial overestimations. On March 30, University of Washington researchers projected that California would need 4,800 beds on April 3. In fact, the state needed 2,200. The same model projected that Louisiana would need 6,400; in fact, it used only 1,700. Even New York, the most stressed system in the country, used only 15,000 beds against a projection of 58,000. It’s best to plan for the worst, but this has meant that patients with other pressing illnesses might have been denied care — or not sought care — for no good reason.
Why is this happening? The modelers are doing their best with what data they can get, much of which initially came from China and Italy. One key number is the fatality rate — the percent of people who will die from the disease. To get that you need to know two numbers: how many people are infected and how many die. The second number is relatively easy to obtain — deaths are recorded (though it isn’t always clear whether someone died of COVID-19 or other causes). But the number infected is very hard to determine. The only way to get it is by testing widely and randomly, testing people who have symptoms and don’t have symptoms, to get a representative sample of the whole country. Almost no country has such samples — least of all America, where testing remains woefully inadequate, incomplete and slow.
A group of Stanford scholars believe that the basic reason that estimates of deaths are being revised downwards is simple: more people have the disease than we thought. That means the denominator is larger than initial estimates and the fatality rate for COVID-19 is lower. (If two out of 100 people with the virus die, the fatality rate is 2 percent; if two out of 1,000 die, it is 0.2 percent). In March, the WHO announced that 3.4 percent of people with the virus had died from it. That would be an astonishingly high fatality rate. Fauci suggested a week later that the actual rate was probably 1 percent, which would still be 10 times as high as the flu. Since then, we have learned that many people, perhaps as many as half, don’t have any symptoms. Some studies find that 75 percent to 80 percent of people infected could be asymptomatic. That means most people infected with the virus never get to a clinic and never get counted.
Stanford’s John Ioannidis, an epidemiologist who specializes in analyzing data and one of the most cited scientists in the field, believes that we have massively overestimated the fatality of COVID-19. “When you have a model involving exponential growth, if you make a small mistake in the base numbers, you end up with a final number that could be off 10-fold, 30-fold, even 50-fold,” he told me. He pointed out that there have been three instances where we have tested an entire population — the Diamond Princess cruise ship; the Italian town of Vo Eugeano; and San Miguel County, Colorado.
In all these places, the numbers who were actually infected (many with no symptoms) — when adjusted for the U.S. population as a whole — suggest a fatality rate that is actually similar to the seasonal flu. Data from Iceland and Denmark, which have done the best random sampling, also point in the same direction, Ioannidis said. “If I were to make an informed estimate based on the limited testing data we have, I would say that COVID-19 will result in fewer than 40,000 deaths this season in the USA,” he told me.
We have shut down the economy based on models, understandably worried about worst-case scenarios. But models are only as good as the data that shapes them. And reopening the economy will depend crucially on mass testing. South Korea has been able to tackle the virus without lockdowns precisely because it has handled testing superbly. Surely the most urgent task for the federal government is to get widespread, randomized testing in place, gather the best data in the world and make policy based on that. Otherwise we will continue to fly blind through this crisis, a crisis that might last longer than it needs to.
Fareed Zakaria’s email address is fareed.zakaria.gps@turner.com.
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